RT Journal Article
T1 Recent advances in practical methods for liver cell biology: a short overview
A1 Torres, Sandra
A1 Abdullah, Zeinab
A1 Brol, Maximilian J.
A1 Hellerbrand, Claus
A1 Fernández, Mercedes
A1 Fiorotto, Romina
A1 Klein, Sabine
A1 Königshofer, Philipp
A1 Liedtke, Christian
A1 Lotersztajn, Sophie
A1 Nevzorova, Yulia
A1 Schierwagen, Robert
A1 Reiberger, Thomas
A1 Uschner, Frank Erhard
A1 Tacke, Frank
A1 Weiskirchen, Ralf
A1 Trebicka, Jonel
AB Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.
PB MDPI
SN 1661-6596, ESSN: 1422-0067
YR 2020
FD 2020-03-16
LK https://hdl.handle.net/20.500.14352/6286
UL https://hdl.handle.net/20.500.14352/6286
LA eng
NO Unión Europea. Horizonte 2020
NO Deutsche Forschungsgemeinschaft
NO European Association for the Study of  the Liver (ESAL)
NO European Foundation for the study of chronic liver failure (EFCLIF)
NO Bayer
DS Docta Complutense
RD 25 abr 2025