RT Journal Article
T1 Complexity analysis of spontaneous brain activity in alzheimer disease and mild cognitive impairment: An MEG study
A1 Fernández, Alberto
A1 Hornero, Roberto
A1 Gómez, Carlos
A1 Turrero, Agustín
A1 Gil Gregorio, Pedro
A1 Matías Santos, Juan
A1 Ortiz, Tomás
AB Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such “normal” tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia.
PB Wolters Kluwer Health
SN 0893-0341
YR 2010
FD 2010-04
LK https://hdl.handle.net/20.500.14352/44643
UL https://hdl.handle.net/20.500.14352/44643
LA eng
DS Docta Complutense
RD 7 may 2024