RT Journal Article
T1 An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
A1 Martínez de Toda, Irene
A1 Vida, Carmen
A1 Fuente del Rey, Mónica de la
AB The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity.
PB MDPI
SN 1422-0067
YR 2017
FD 2017-07-24
LK https://hdl.handle.net/20.500.14352/19138
UL https://hdl.handle.net/20.500.14352/19138
LA eng
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 27 abr 2024