RT Journal Article
T1 Prognostic Value of the PROFUND Index for 30-Day Mortality in Acute Heart Failure
A1 Méndez Bailón, Manuel
A1 Iguarán Bermúdez, Rosario
A1 López García, Lidia
A1 Sánchez Sauce, Beatriz
A1 Pérez Mateos, Pablo
A1 Barrado Cuchillo, Julia
A1 Villar Martínez, Miguel
A1 Fernández Castelao, Santiago
A1 García Klepzig, José Luis
A1 Fuentes Ferrer, Manuel
A1 García García, Alejandra
A1 Vila Costa, Isidro
A1 Miguel Yanes, José María De
A1 Casas Rojo, José
A1 Calvo Manuel, Elpidio
A1 Andrès, Emmanuel
A1 Lorenzo Villalba, Noel
AB Background and Objectives: The prevalence and incidence of heart failure (HF) have been increasing in recent years as the population ages. These patients show a distinct profile of comorbidity, which makes their care more complex. In recent years, the PROFUND index, a specific tool for estimating the mortality rate at one year in pluripathology patients, has been developed. The aim of this study was to evaluate the prognostic value of the PROFUND index and of in-hospital and 30-day mortality after discharge of patients admitted for acute heart failure (AHF).Materials and Methods: A prospective multicenter longitudinal study was performed that included patients admitted with AHF and ≥2 comorbid conditions. Clinical, analytical, and prognostic variables were collected. The PROFUND index was collected in all patients and rates of in-hospital and 30-day mortality after discharge were analyzed. A bivariate analysis was performed with quantitative variables between patients who died and those who survived at the 30-day follow-up. A logistic regression analysis was performed with the variables that obtained statistical significance in the bivariate analysis between deceased and surviving subjects.Results: A total of 128 patients were included. Mean age was 80.5 +/− 9.98 years, and women represented 51.6%. The mean PROFUND index was 5.26 +/− 4.5. The mortality rate was 8.6% in-hospital and 20.3% at 30 days. Preserved left ventricular ejection fraction was found in 60.9%. In the sample studied, there were patients with a PROFUND score < 7 predominated (89 patients (70%) versus 39 patients (31%) with a PROFUND score ≥ 7). Thirteen patients (15%) with a PROFUND score < 7 died versus the 13 (33%) with a PROFUND score ≥ 7, p = 0.03. Twelve patients (15%) with a PROFUND score < 7 required readmission versus 12 patients (35%) with a PROFUND score ≥ 7, p = 0.02. The ROC curve of the PROFUND index for in-hospital mortality and 30-day follow-up in patients with AHF showed AUC 0.63, CI: 95% (0.508–0.764), p <0.033. Conclusions: The PROFUND index is a clinical tool that may be useful for predicting short-term mortality in elderly patients with AHF. Further studies with larger simple sizes are required to validate these results.
PB MPDI
SN 1648-9144
YR 2021
FD 2021-10-23
LK https://hdl.handle.net/20.500.14352/4831
UL https://hdl.handle.net/20.500.14352/4831
LA eng
NO Méndez Bailón, M., Iguarán Bermúdez, R., López García, L. et al. «Prognostic Value of the PROFUND Index for 30-Day Mortality in Acute Heart Failure». Medicina, vol. 57, n.o 11, octubre de 2021, p. 1150. Crossref, https://doi.org/10.3390/medicina57111150.
DS Docta Complutense
RD 4 abr 2025