RT Journal Article
T1 Herpesvirus Antibodies, Vitamin D and Short-Chain Fatty Acids: Their Correlation with Cell Subsets in Multiple Sclerosis Patients and Healthy Controls
A1 Domínguez Mozo, María Inmaculada
A1 Pérez Pérez, Silvia
A1 Villarrubia, Noelia
A1 Costa Frossard, Lucienne
A1 Fernández Velasco, Jose Ignacio
A1 Ortega Madueño, Isabel
A1 García Martínez, María Angel
A1 García Calvo, Estefanía
A1 Estévez Sánchez, Héctor
A1 Luque García, José Luis
A1 Torrejón, Maria Josefa
A1 Arroyo, Rafael
A1 Villar, Luisa Maria
A1 Álvarez Lafuente, Roberto
AB Although the etiology of multiple sclerosis (MS) is still unknown, it is commonly accepted that environmental factors could contribute to the disease. The objective of this study was to analyze the humoral response to Epstein-Barr virus, human herpesvirus 6A/B and cytomegalovirus, and the levels of 25-hydroxyvitamin D (25(OH)D) and the three main short-chain fatty acids (SCFA), propionate (PA), butyrate (BA) and acetate (AA), in MS patients and healthy controls (HC) to understand how they could contribute to the pathogenesis of the disease. With this purpose, we analyzed the correlations among them and with different clinical variables and a wide panel of cell subsets. We found statistically significant differences for most of the environmental factors analyzed when we compared MS patients and HC, supporting their possible involvement in the disease. The strongest correlations with the clinical variables and the cell subsets analyzed were found for 25(OH)D and SCFAs levels. A correlation was also found between 25(OH)D and PA/AA ratio, and the interaction between these factors negatively correlated with interleukin 17 (IL-17)-producing CD4+ and CD8+ T cells in untreated MS patients. Therapies that simultaneously increase vitamin D levels and modify the proportion of SCFA could be evaluated in the future.
PB MPDI
SN 2073-4409
YR 2021
FD 2021-01-10
LK https://hdl.handle.net/20.500.14352/7130
UL https://hdl.handle.net/20.500.14352/7130
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
DS Docta Complutense
RD 24 abr 2025