RT Journal Article
T1 Delineation of the olive pollen proteome and its allergenome unmasks cyclophilin as a relevant cross-reactive allergen
A1 San Segundo Acosta, Pablo
A1 Oeo Santos, Carmen
A1 Benedé Pérez, Sara
A1 de los Ríos, Vivian
A1 Navas, Ana
A1 Ruiz Leon, Berta
A1 Moreno, Carmen
A1 Pastor Vargas, Carlos
A1 Jurado, Aurora
A1 Villalba, Mayte
A1 Villalba Díaz, María Teresa
A1 Barderas Manchado, Rodrigo
AB Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome. A total of 1907 proteins were identified by LC–MS/MS using predicted protein sequences from its genome. Most proteins (60%) were predicted to possess catalytic activity and be involved in metabolic processes. In total, 203 proteins belonging to 47 allergen families were found in olive pollen. A peptidyl–prolyl cis–trans isomerase, cyclophilin, produced in Escherichia coli, was found as a new olive pollen allergen (Ole e 15). Most Ole e 15-sensitized patients were children (63%) and showed strong IgE recognition to the allergen. Ole e 15 shared high sequence identity with other plant, animal, and fungal cyclophilins and presented high IgE cross-reactivity with pollen, plant food, and animal extracts.
PB ACS Publications
SN 1535-3893
SN 1535-3907
YR 2019
FD 2019-06-13
LK https://hdl.handle.net/20.500.14352/109596
UL https://hdl.handle.net/20.500.14352/109596
LA eng
NO San Segundo-Acosta P, Oeo-Santos C, Benedé S, de Los Ríos V, Navas A, Ruiz-Leon B, Moreno C, Pastor-Vargas C, Jurado A, Villalba M, Barderas R. Delineation of the Olive Pollen Proteome and Its Allergenome Unmasks Cyclophilin as a Relevant Cross-Reactive Allergen. J Proteome Res. 2019 Aug 2;18(8):3052-3066. doi: 10.1021/acs.jproteome.9b00167. Epub 2019 Jun 27. PMID: 31192604.
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos II
NO Comunidad de Madrid
NO Junta de Andalucía
DS Docta Complutense
RD 23 ene 2026