RT Journal Article
T1 Multiscale detrended cross-correlation coefficient: estimating coupling in non-stationary neurophysiological signals
A1 Stylianou, Orestis
A1 Susi, Gianluca
A1 Hoffmann, Martin
A1 Suárez Méndez, Isabel
A1 López Sanz, David
A1 Schirner, Michael
A1 Ritter, Petra
AB The brain consists of a vastly interconnected network of regions, the connectome. By estimating the statistical interdependence of neurophysiological time series, we can measure the functional connectivity (FC) of this connectome. Pearson’s correlation (rP) is a common metric of coupling in FC studies. Yet rP does not account properly for the non-stationarity of the signals recorded in neuroimaging. In this study, we introduced a novel estimator of coupled dynamics termed multiscale detrended cross-correlation coefficient (MDC3). Firstly, we showed that MDC3 had higher accuracy compared to rP and lagged covariance using simulated time series with known coupling, as well as simulated functional magnetic resonance imaging (fMRI) signals with known underlying structural connectivity. Next, we computed functional brain networks based on empirical magnetoencephalography (MEG) and fMRI. We found that by using MDC3 we could construct networks of healthy populations with significantly different properties compared to rP networks. Based on our results, we believe that MDC3 is a valid alternative to rP that should be incorporated in future FC studies.
PB Frontiers Media
SN 1662-4548
YR 2024
FD 2024-11-13
LK https://hdl.handle.net/20.500.14352/134509
UL https://hdl.handle.net/20.500.14352/134509
LA eng
NO Stylianou, Orestis, et al. «Multiscale detrended cross-correlation coefficient: estimating coupling in non-stationary neurophysiological signals». Frontiers in Neuroscience, vol. 18, noviembre de 2024, p. 1422085. DOI.org (Crossref), https://doi.org/10.3389/fnins.2024.1422085.
NO © 2024 Stylianou, Susi, Hoffmann,Suárez-Méndez, López-Sanz, Schirner andRitter.
NO Consejo Europeo de Investigación
NO Fundación Alemana de Investigación
NO SPP Computational Connectomics (Alemania)
NO Berlin Institute of Health & Foundation Charité (Alemania)
NO Johanna Quandt Excellence Initiative
NO ERAPerMed Pattern-Cog
NO European Commission
DS Docta Complutense
RD 28 abr 2026