RT Journal Article T1 Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders A1 García Prieto, Concha A1 Fernández Alfonso, María Soledad AB Caloric restriction (CR) has proved to be the most effective and reproducible dietary intervention to increase healthy lifespan and aging. A reduction in cardiovascular disease (CVD) risk in obese subjects can be already achieved by a moderate and sustainable weight loss. Since pharmacological approaches for body weight reduction have, at present, a poor long-term efficacy, CR is of great interest in the prevention and/or reduction of CVD associated with obesity. Other dietary strategies changing specific macronutrients, such as altering carbohydrates, protein content or diet glycemic index have been also shown to decrease the progression of CVD in obese patients. In this review, we will focus on the positive effects and possible mechanisms of action of these strategies on vascular dysfunction. PB MDPI SN 2072-6643 YR 2016 FD 2016-06-15 LK https://hdl.handle.net/20.500.14352/23917 UL https://hdl.handle.net/20.500.14352/23917 LA eng NO Ministerio de Ciencia e Innovación (MICINN) NO Banco Santander NO Fundación Mutua Madrileña NO Fundación Eugenio Rodríguez Pascual DS Docta Complutense RD 17 may 2024