RT Journal Article
T1 The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
A1 De las Heras Molina, Ana
A1 Estellé, Jordi
A1 Vázquez Gómez, Marta
A1 López García, Adrián
A1 Pesantez Pacheco, José Luis
A1 Astiz, Susana
A1 Garcia Contreras, Consolación
A1 Escudero Portugués, Rosa María
A1 Isabel Redondo, Beatriz
A1 Gonzalez Bulnes, Antonio
A1 Óvilo, Cristina
AB The gut microbiota of the pig is being increasingly studied due to its implications for host homeostasis and the importance of the pig as a meat source and biomedical model of human diseases. However, most studies comparing the microbiome between different breeds do not consider the influence of maternal environment during the colonization of the microbiota. The aim of the present study was to compare the gut microbiota during postnatal growth between two pig genotypes (purebred Iberian vs. crossbreds Iberian x Large White pigs), gestated in a single maternal environment (pure Iberian mothers) inseminated with heterospermic semen. Postnatally, piglets were maintained in the same environmental conditions, and their microbiota was studied at 60 and 210 days old. Results showed that age had the greatest influence on alpha and beta diversity, and genotype also affected beta diversity at both ages. There were differences in the microbiome profile between genotypes at the ASV and genus levels when jointly analyzing the total number of samples, which may help to explain phenotypical differences. When each time-point was analyzed individually, there were more differences at 210 days-old than 60 days-old. Fecal short-chain fatty acids (SCFA) were also affected by age, but not by genotype. These results may be a basis for further research on host genotype interactions with the gut microbiota
PB Public Library of Science
YR 2024
FD 2024-12-09
LK https://hdl.handle.net/20.500.14352/114002
UL https://hdl.handle.net/20.500.14352/114002
LA eng
NO Heras-Molina, A., Estellé, J., Vázquez-Gómez, M., López-García, A., Pesantez-Pacheco, J.-L., Astiz, S., Garcia-Contreras, C., Escudero, R., Isabel, B., Gonzalez-Bulnes, A., & Óvilo, C. (2024). The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences. PLoS ONE, 19(12). https://doi.org/10.1371/JOURNAL.PONE.0315199
NO Author Contributions Conceptualization: Beatriz Isabel, Antonio Gonzalez-Bulnes, Cristina O´ vilo. Data curation: Ana Heras-Molina, Jordi Estelle´, Adria´n Lo´pez-Garcı´a, Rosa Escudero. Formal analysis: Ana Heras-Molina, Jordi Estelle´, Rosa Escudero. Funding acquisition: Beatriz Isabel, Antonio Gonzalez-Bulnes, Cristina O´ vilo. Investigation: Ana Heras-Molina, Marta Va´zquez-Go´mez, Jose´-Luis Pesantez-Pacheco, Susana Astiz, Consolacio´n Garcia-Contreras, Rosa Escudero, Beatriz Isabel, Antonio Gonzalez-Bulnes, Cristina O´ vilo. Methodology: Jordi Estelle´, Adria´n Lo´pez-Garcı´a, Cristina O´ vilo. Project administration: Beatriz Isabel, Antonio Gonzalez-Bulnes, Cristina O´ vilo. Resources: Marta Va´zquez-Go´mez, Adria´n Lo´pez-Garcı´a, Jose´-Luis Pesantez-Pacheco, Susana Astiz, Consolacio´n Garcia-Contreras, Antonio Gonzalez-Bulnes. Software: Jordi Estelle´. Supervision: Adria´n Lo´pez-Garcı´a, Susana Astiz, Beatriz Isabel, Cristina O´ vilo. Validation: Ana Heras-Molina, Marta Va´zquez-Go´mez, Consolacio´n Garcia-Contreras, Beatriz Isabel. Writing – original draft: Ana Heras-Molina. Writing – review & editing: Jordi Estelle´, Marta Va´zquez-Go´mez, Adria´n Lo´pez-Garcı´a, Jose´- Luis Pesantez-Pacheco, Susana Astiz, Consolacio´n Garcia-Contreras, Rosa Escudero, Beatriz Isabel, Antonio Gonzalez-Bulnes, Cristina O´ vilo
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 7 abr 2025