RT Journal Article
T1 In-vivo evaluation of tamoxifen-loaded microspheres based on mixtures of poly (D,L-lactide-co-glycolide)and poly (D,L-lactide) polymers
A1 Fernández Olleros, Ana M.
A1 Olmo López, Rosa María
A1 Muñiz Hernando, Enriqueta
A1 Lozano Fernández, Rafael
A1 Teijón Rivera, José María
A1 Blanco Gaitán, María Dolores
AB Microspheres of different proportions of poly-(D,L-lactideco-glycolide) and poly-(D,L-lactide) were formulated by spray drying as a drug-delivery system for the treatment of breast cancer with tamoxifen. These systems had been evaluated previously in vitro and showed very positive results that have led to further assessment in vivo. This work evaluates the performance of these systems in an organism by carrying out a study in female Wistar rats. Microspheres were subcutaneously injected into the back of rats for the assessment of not only the biocompatibility but also the release of the drug contained and its biodistribution. As, in vitro, these systems could release the drug under physiological conditions; different plasma concentrations of tamoxifen and one of its metabolites, 4-hydroxy-tamoxifen, were achieved depending on the polymer composition. Microspheres could reduce the accumulation of the drug in different nontarget organs and presented good biocompatibility.
PB Lippincott, Williams & Wilkins
SN 0959-4973, ESSN: 1473-5741
YR 2014
FD 2014-07
LK https://hdl.handle.net/20.500.14352/35632
UL https://hdl.handle.net/20.500.14352/35632
LA eng
NO Fernández Olleros, A. M., Olmo López, R. M., Muñiz Hernando, E. et al. «In-Vivo Evaluation of Tamoxifen-Loaded Microspheres Based on Mixtures of Poly (D,L-Lactide-Co-Glycolide) and Poly (D,L-Lactide) Polymers». Anti-Cancer Drugs, vol. 25, n.o 6, julio de 2014, pp. 641-51. Crossref, https://doi.org/10.1097/cad.0000000000000087.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Fundación Médica Mutua Madrileña
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 9 abr 2025