RT Journal Article T1 A Proxy Approach to Family Involvement and Neurocognitive Function in First Episode of Non-Affective Psychosis: Sex-Related Differences A1 Soler Andrés, Marina A1 Díaz Pons, Alexandre A1 Ortiz García de la Foz, Víctor A1 Murillo García, Nancy A1 Barrio Martínez, Sara A1 Miguel Corredera, Margarita A1 Yorca Ruiz, Angel A1 Magdaleno Herrero, Rebeca A1 Moya Higueras, Jorge A1 Setién Suero, Esther A1 Ayesa Arriola, Rosa AB Schizophrenia spectrum disorders (SSD) often show cognitive deficits (CD) impacting daily life. Family support has been shown to be protective against CD, yet the relationship between these in psychotic patients remains complex and not fully understood. This study investigated the association between a subdomain of family support, namely, family involvement (estimated through a proxy measure), cognitive functioning, and sex in first-episode psychosis (FEP) patients. The sample included 308 patients enrolled in the Program for Early Phases of Psychosis (PAFIP), divided into 4 groups based on their estimated family involvement (eFI) level and sex, and compared on various variables. Women presented lower rates of eFI than men (37.1% and 48.8%). Higher eFI was associated with better cognitive functioning, particularly in verbal memory. This association was stronger in women. The findings suggest that eFI may be an important factor in FEP patients’ cognitive functioning. This highlights the importance of including families in treatment plans for psychotic patients to prevent CD. Further research is needed to better understand the complex interplay between family support, sex, and cognitive functioning in psychotic patients and develop effective interventions that target these factors. PB MDPI SN 2227-9032 YR 2023 FD 2023-06-30 LK https://hdl.handle.net/20.500.14352/103672 UL https://hdl.handle.net/20.500.14352/103672 LA eng NO Soler-Andrés, M.; Díaz-Pons, A.; Ortiz-García de la Foz, V.; Murillo-García, N.; Barrio- Martínez, S.; Miguel-Corredera, M.; Yorca-Ruiz, A.; Magdaleno Herrero, R.; Moya-Higueras, J.; Setién-Suero, E.; et al. A Proxy Approach to Family Involvement and Neurocognitive Function in First Episode of Non-Affective Psychosis: Sex-Related Differences. Healthcare 2023, 11, 1902. https://doi.org/10.3390/ healthcare11131902 NO Insituto de Salud Carlos III NO Instituto de Investigación Biomédica Valdecilla (España) NO Universidad de Cantabria (España) DS Docta Complutense RD 10 sept 2024