RT Journal Article
T1 Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
A1 Mulder, Jan
A1 Aguado Sánchez, Tania
A1 Keimpema, Erik
A1 Barabás, Klaudia
A1 Ballester Rosado, Carlos
A1 Nguyen, Laurent
A1 Monory, Krisztina
A1 Marsicano, Giovanni
A1 Di Marzo, Vincenzo
A1 Hurd, Yasmin
A1 Guillemot, Francois
A1 Mackie, Ken
A1 Lutz, Beat
A1 Guzmán Pastor, Manuel
A1 Lu, Hui Chen
A1 Galve Roperh, Ismael
A1 Harkany, Tibor
AB Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions during pyramidal cell specification and establishment of long-range axonal connections are unknown. Here, we show that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of immature pyramidal cells. When layer patterning is accomplished, developing pyramidal cells rely on eCB signaling to initiate the elongation and fasciculation of their long-range axons. Accordingly, CB1 cannabinoid receptor (CB1R) null and pyramidal cell-specific conditional mutant (CB1Rf/f,NEX-Cre) mice develop deficits in neuronal progenitor proliferation and axon fasciculation. Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB1Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis.
PB National Academy of Sciences
SN 0027-8424
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/91636
UL https://hdl.handle.net/20.500.14352/91636
LA eng
NO Mulder, Jan, et al. «Endocannabinoid Signaling Controls Pyramidal Cell Specification and Long-Range Axon Patterning». Proceedings of the National Academy of Sciences, vol. 105, n.o 25, junio de 2008, pp. 8760-65. https://doi.org/10.1073/pnas.0803545105.
NO National Institutes of Health 
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
NO Alzheimer's Research Trust
NO Alzheimer's Association
NO Swedish Medical Research Council
NO Scottish Universities Life Science Alliance
NO German Research Foundation
DS Docta Complutense
RD 31 dic 2025