RT Journal Article
T1 Theory of force-extension curves for modular proteins and DNA hairpins
A1 Bonilla, Luis L.
A1 Carpio Rodríguez, Ana María
A1 Prados, Antonio
AB We study a model describing the force-extension curves of modular proteins, nucleic acids, and other biomolecules made out of several single units or modules. At a mesoscopic level of description, the configuration of the system is given by the elongations of each of the units. The system free energy includes a double-well potential for each unit and an elastic nearest-neighbor interaction between them. Minimizing the free energy yields the system equilibrium properties whereas its dynamics is given by (overdamped) Langevin equations for the elongations, in which friction and noise amplitude are related by the fluctuation-dissipation theorem. Our results, both for the equilibrium and the dynamical situations, include analytical and numerical descriptions of the system force-extension curves under force or length control and agree very well with actual experiments in biomolecules. Our conclusions also apply to other physical systems comprising a number of metastable units, such as storage systems or semiconductor superlattices.
PB American Physical Society
SN 1539-3755
YR 2015
FD 2015-05
LK https://hdl.handle.net/20.500.14352/24096
UL https://hdl.handle.net/20.500.14352/24096
LA eng
NO Bonilla, L. L., Carpio Rodríguez, A. M. Prados, A. «Theory of Force-Extension Curves for Modular Proteins and DNA Hairpins». Physical Review E, vol. 91, n.o 5, mayo de 2015, p. 052712. DOI.org (Crossref), https://doi.org/10.1103/PhysRevE.91.052712.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 10 abr 2025