RT Journal Article
T1 Ocular Vascular Changes in Mild Alzheimer’s Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis
A1 García Martín, Elena Salobrar
A1 Méndez Hernández, Carmen D.
A1 Hoz Montañana, Rosa de
A1 Ramírez Sebastián, Ana Isabel
A1 López Cuenca, Inés
A1 Fernández Arrabal, José A.
A1 Rojas Lozano, Pilar
A1 Wang, Surina
A1 García Feijoo, Julián
A1 Gil, Pedro
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
AB In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (Aβ) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are related to decreased vascular density and low blood flow. In patients with Alzheimer’s disease, thinning of the choroid and the retina has been shown. The aim of this prospective study was to assess the retinal and choroidal vascular systems, analyzing the choroidal thickness with optical coherence tomography (OCT), the foveal avascular zone (FAZ) with OCT-angiography (OCTA), and the optic nerve head (ONH) hemoglobin with the Laguna ONhE program, to evaluate which of the two ocular vascular systems shows earlier changes in mild AD patients. These patients, compared to controls, showed a significantly thinner choroid at all the analyzed points, with the exception of the temporal macula (at 1000 and 1500 µm from the fovea). On the other hand, the FAZ and ONH hemoglobin did not show significant differences. In conclusion, a thinner choroid was the main ocular vascular change observed in mild AD patients, while the retinal vessels were not yet affected. Therefore, choroidal thickness could be used an early biomarker in AD.
PB MDPI
SN 2075-4426
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/7538
UL https://hdl.handle.net/20.500.14352/7538
LA eng
NO Received: 14 August 2020 / Revised: 4 November 2020 / Accepted: 13 November 2020 / Published: 15 November 2020
NO Ministerio de Economía y Competitividad (MINECO)/Instituto de Salud Carlos III
NO ISCIII-Subdirección General de Redes y Centros de Investigación Cooperativa/FEDER
NO Ministerio de Ciencia e Innovación (MICINN)
NO Universidad Complutense de Madrid (España)
DS Docta Complutense
RD 2 may 2024