RT Journal Article T1 FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration A1 Cabrera Martín, María Nieves A1 Nespral, Pedro A1 Valles-Salgado, Maria A1 Bascuñana, Pablo A1 Delgado-Alonso, Cristina A1 Delgado Álvarez, Alfonso A1 Fernández-Romero, Lucía A1 López-Carbonero, Juan Ignacio A1 Díez-Cirarda, María A1 Gil-Moreno, María José A1 Matías-Guiu Guía, Jorge A1 Matias-Guiu, Jordi A. AB Introduction: The Addenbrooke’s Cognitive Examination III (ACE-III) is a brief test useful for neuropsychological assessment. Several studies have validated the test for the diagnosis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, we aimed to examine the metabolic correlates associated with the performance of ACE-III in AD and behavioral variant FTD. Methods: We enrolled 300 participants in a cross-sectional study, including 180 patients with AD, 60 with behavioral FTD (bvFTD), and 60 controls. An 18F-Fluorodeoxyglucose positron emission tomography study was performed in all cases. Correlation between the ACE-III and its domains (attention, memory, fluency, language, and visuospatial) with the brain metabolism was estimated. Results: The ACE-III showed distinct neural correlates in bvFTD and AD, effectively capturing the most relevant regions involved in these disorders. Neural correlates differed for each domain, especially in the case of bvFTD. Lower ACE-III scores were associated with more advanced stages in both disorders. The ACE-III exhibited high discrimination between bvFTD vs. HC, and between AD vs. HC. Additionally, it was sensitive to detect hypometabolism in brain regions associated with bvFTD and AD. Conclusion: Our study contributes to the knowledge of the brain regions associated with ACE-III, thereby facilitating its interpretation, and highlighting its suitability for screening and monitoring. This study provides further validation of ACE-III in the context of AD and FTD. PB Frontiers SN 1664-1078 YR 2023 FD 2023-11 LK https://hdl.handle.net/20.500.14352/103889 UL https://hdl.handle.net/20.500.14352/103889 LA eng NO Cabrera-Martín MN, Nespral P, Valles-Salgado M, Bascuñana P, Delgado-Alonso C, Delgado-Álvarez A, Fernández-Romero L, López-Carbonero JI, Díez-Cirarda M, Gil-Moreno MJ, Matías-Guiu J and Matias-Guiu JA (2023) FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration. Front. Psychol. 14:1273608. doi: 10.3389/fpsyg.2023.1273608 DS Docta Complutense RD 7 abr 2025