RT Journal Article
T1 Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases
A1 Cuesta, Fernando de la
A1 Álvarez Llamas, Gloria
A1 Gil Dones, Félix
A1 Martin-Rojas, Tatiana
A1 Zubiri, Irene
A1 Pastor Vargas, Carlos
A1 Barderas, Maria
A1 Vivanco Martínez, Fernando
AB Atherosclerosis is a disease with higher levels of mortality in developed countries. Comprehension of the molecular mechanisms can yield very useful information in clinics for prevention, diagnosis and recovery monitoring. Proteomics represents an ideal methodology for this purpose, as proteins constitute the effectors of the different biological processes running during pathogenesis. To date, studies in atherosclerosis have been mainly focused on the search for plasma biomarkers. However, tissue proteomics allows going deeper into tissue secretomes, arterial layers or particular cells of interest, which, in turn, constitutes a more direct approximation to in vivo operating mechanisms. The aim of this review is to report latest advances in tissue proteomics in atherosclerosis and related diseases (e.g., aortic stenosis and ischemic injury).
PB Taylor & Francis
SN 1478-9450
YR 2009
FD 2009
LK https://hdl.handle.net/20.500.14352/94376
UL https://hdl.handle.net/20.500.14352/94376
LA eng
NO de la Cuesta F, Alvarez-Llamas G, Gil-Dones F, Martin-Rojas T, Zubiri I, Pastor C, Barderas MG, Vivanco F. Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases. Expert Rev Proteomics. 2009 Aug;6(4):395-409. doi: 10.1586/epr.09.60. PMID: 19681675.
NO Ministerio de Ciencia y Educación (España)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 6 oct 2024