RT Journal Article
T1 Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study
A1 Carracedo Rodríguez, Juan Gonzalo
A1 Recchioni, Alberto
A1 Alejandre Alba, Nicolás
A1 Martín Gil, Alba
A1 Crooke Álvarez, Almudena
A1 Jiménez Alfaro-Morote, Ignacio
A1 Pintor Just, Jesús Jerónimo
AB Purpose: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus healthy subjects.Methods: A total of 15 KC patients (KC group, n = 15 eyes) and 16 healthy subjects (control group, 16 eyes) were enrolled in this study. The Schirmer I test with no anesthetic, tear break-up time (TBUT), corneal staining characteristics, and ocular surface disease index (OSDI) scores were evaluated for both groups. Impression cytology, combined with/scanning laser confocal microscopy (LCM), was performed to evaluate goblet cell density, mucin cloud height (MCH), and goblet cell layer thickness (CLT). Finally, tear concentrations of di-adenosine tetraphosphate (Ap4A) were assessed. Results were statistically analyzed using Shapiro–Wilk and non-parametric Wilcoxon rank sum tests. Statistical significance was set at p < 0.05.Results: KC patients had lower tear volumes and greater corneal staining than did healthy subjects (p < 0.05). OSDI scores were 44.96 ± 8.65 and 17.78 ± 6.50 for the KC and control groups, respectively (p < 0.05). We found no statistically significant differences in TBUT between groups. Impression cytology revealed lower goblet cell densities in KC group patients versus control group subjects (84.88 ± 32.98 and 128.88 ± 50.60 cells/mm,2 respectively, p < 0.05). There was a statistically significant reduction in MCH and CLT in KC group patients compared with control group subjects. Ap4A tear concentrations were higher in KC group patients than in control group subjects (2.56 ± 1.10 and 0.15 ± 0.12 µM, respectively, p < 0.05).Conclusions: The parameters evaluated in this study indicate that KC patients suffer greater symptoms of dry eye and greater tear instability, primarily due to the decreased mucin production in their tears, than do healthy patients with no KC.
PB Taylor & Francis
SN 0271-3683
YR 2015
FD 2015-11
LK https://hdl.handle.net/20.500.14352/24620
UL https://hdl.handle.net/20.500.14352/24620
LA eng
NO Carracedo Rodríguez, J. G., Recchioni, A., Alejandre Alba, N. et al. «Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study». Current Eye Research, vol. 40, n.o 11, noviembre de 2015, pp. 1088-94. DOI.org (Crossref), https://doi.org/10.3109/02713683.2014.987871.
NO Received 13 December 2013; revised 4 November 2014; accepted 9 November 2014; published online 9 December 2014
DS Docta Complutense
RD 22 jul 2024