RT Journal Article
T1 Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
A1 Bru Espino, Antonio Leonardo
A1 Gómez Castro, David
A1 Vila, Luis
A1 Brú, Isabel
A1 Souto, J. C.
AB BackgroundPeritumoral inflammation—a response mainly involving polimorphonuclear neutrophils—has traditionally been thought protumoral in its effects. In recent years, however, a number of studies have indicated that it may play an important antitumoral role. This discrepancy has been difficult to explain.Methods and findingsThis work describes a tool for simulating tumor growth that obeys the universal model of tumor growth dynamics, and shows through its use that low intensity peritumoral inflammation exerts a protumoral effect, while high intensity inflammation exerts a potent antitumoral effect. Indeed, the simulation results obtained indicate that a sufficiently strong antitumoral effect can reverse tumor growth, as has been suggested several times in the clinical literature.ConclusionsThe present result indicate that an ‘immunological threshold’ must exist, marking the boundary between states in which peritumoral inflammation is either harmful or beneficial. These findings lend support to the idea that stimulating intense peritumoral inflammation could be used as a treatment against solid tumors.
PB Public Library Science
SN 1932-6203
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/12901
UL https://hdl.handle.net/20.500.14352/12901
LA eng
NO Bru Espino, A. L., Gómez Castro, D., Vila, L. et al. «Study of Tumor Growth Indicates the Existence of an “Immunological Threshold” Separating States of pro- and Antitumoral Peritumoral Inflammation». PLOS ONE, editado por Ilya Ulasov, vol. 13, n.o 11, noviembre de 2018, p. e0202823. DOI.org (Crossref), https://doi.org/10.1371/journal.pone.0202823.
DS Docta Complutense
RD 24 abr 2025