RT Journal Article
T1 Stellate cell computational modeling predicts signal flteringin the molecular layer circuit of cerebellum
A1 Rizza, Martina Francisca
A1 Locatelli, Francesca
A1 Masoli, Stefano
A1 Sánchez‑Ponce, Diana
A1 Muñoz Céspedes, Alberto
A1 Prestori, Francesca
A1 D’Angelo, Egidio
AB The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fber bursts. Stellate cells showed intrinsic pacemaking, along with characteristic responses to depolarization and hyperpolarization, and showed a marked short-term facilitation during repetitive parallel fber transmission. Spikes were emitted after a lag and only at high frequency, making stellate cells to operate as delay-high-pass flters. A detailed computational model summarizing these physiological properties allowed to explore diferent functional confgurations of the parallel fber—stellate cell—Purkinje cell circuit. Simulations showed that, following parallel fber stimulation, Purkinje cells almost linearly increased their response with input frequency, but such an increase was inhibited by stellate cells, which leveled the Purkinje cell gain curve to its 4 Hz value. When reciprocal inhibitory connections between stellate cells were activated, the control of stellate cells over Purkinje cell discharge was maintained only at very high frequencies. These simulations thus predict a new role for stellate cells, which could endow the molecular layer with low-pass and band-pass fltering properties regulating Purkinje cell gain and, along with this, also burst delay and the burst-pause responses pattern.
PB Nature Research
SN ESSN: 2045-2322
YR 2021
FD 2021-02-16
LK https://hdl.handle.net/20.500.14352/7200
UL https://hdl.handle.net/20.500.14352/7200
LA eng
NO Unión Europea. Horizonte 2020
NO Centro Fermi (Rome, Italy)
DS Docta Complutense
RD 10 abr 2025