RT Journal Article
T1 Impact of femtosecond laser-assisted in situ keratomileusis on retinal ganglion cell function
A1 Lauzirika, Gorka
A1 Arranz Márquez, Esther
A1 García González, Montserrat
A1 Hernández Verdejo, José Luis
A1 Teus Guezala, Miguel Ángel
AB Purpose: To analyse the effect of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) on the electrical response of retinal ganglion cells using pattern electroretinography (pERG).Methods: This was a longitudinal, prospective, observational pilot study. We included consecutive myopic patients who underwent FS-LASIK to correct up to 6dioptres of myopia and up to 2dioptres of astigmatism. Patients with excessive blinking or tearing and those with Snellen uncorrected visual acuity less than 0.9 dec on postop day 1 were excluded. Diopsys NOVA® (Diopsys Inc., NJ) pERG records, using high- and low-contrast patterns, were obtained 16 h and 1month after FS-LASIK was performed. Magnitude (μV), Magnitude D (μV), Magnitude D/Magnitude ratio and signal-to-noise ratio (dB) were analysed. Wilcoxon test for nonparametric paired data was employed.Results: pERG data from 24 eyes were analysed from 24 patients who underwent FS-LASIK. Mean age was 35.79±9.86 years. Mean preoperative refraction was −2.69±7.6D (spherical) and −0.38±0.40D (cylinder). Mean surgical time was 56.88±7.6s. No statistically significant differences were obtained for any of the studied parameters when comparing 16h with 1month after FS-LASIK, with the exception of Magnitude with low contrast, which increased from 1.21±0.2 to 1.39±0.29µV at 16 h and 1month postoperatively, respectively (p=0.03).Conclusions: FS-LASIK seems to induce a mild and transitory defect in retinal ganglion cell function. Only a mild decrease was detected in the magnitude value for low-contrast stimuli when pERG was performed 16h postoperatively, and it returned to normal 1 month after surgery.
PB Wichtig
SN 1120-6721
YR 2021
FD 2021-07-27
LK https://hdl.handle.net/20.500.14352/4467
UL https://hdl.handle.net/20.500.14352/4467
LA eng
NO Date received: 1 April 2021 / Accepted: 9 July 2021 / First Published: 27 July 2021.
DS Docta Complutense
RD 12 abr 2025