RT Journal Article
T1 From Biomarkers to Models in the Changing Landscape of Chronic Lymphocytic Leukemia: Evolve or Become Extinct
A1 González Gascón y Marín, Isabel
A1 Muñoz Novas, Carolina
A1 Rodríguez Vicente, Ana-Eugenia
A1 Quijada Álamo, Miguel
A1 Hernández Sánchez, María
A1 Pérez Carretero, Claudia
A1 Ramos Ascanio, Victoria
A1 Hernández Rivas, José Ángel
AB hronic lymphocytic leukemia (CLL) is an extremely heterogeneous disease. With the advent of oral targeted agents (Tas) the treatment of CLL has undergone a revolution, which has been accompanied by an improvement in patient’s survival and quality of life. This paradigm shift also affects the value of prognostic and predictive biomarkers and prognostic models, most of them inherited from the chemoimmunotherapy era but with a different behavior with Tas. This review discusses: (i) the role of the most relevant prognostic and predictive biomarkers in the setting of Tas; and (ii) the validity of classic and new scoring systems in the context of Tas. In addition, a critical point of view about predictive biomarkers with special emphasis on 11q deletion, novel resistance mutations, TP53 abnormalities, IGHV mutational status, complex karyotype and NOTCH1 mutations is stated. We also go over prognostic models in early stage CLL such as IPS-E. Finally, we provide an overview of the applicability of the CLL-IPI for patients treated with Tas, as well as the emergence of new models, generated with data from patients treated with Tas.
PB MPDI
SN 2072-6694
YR 2021
FD 2021-04-08
LK https://hdl.handle.net/20.500.14352/6887
UL https://hdl.handle.net/20.500.14352/6887
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
NO Junta de Castilla y León
DS Docta Complutense
RD 29 abr 2024