RT Journal Article
T1 L1CAM binds ErbB receptors through Ig-Like domains coupling cell adhesion and neuregulin signalling
A1 Donier, Emanuelle
A1 Gomez Sanchez, Jose Antonio
A1 Grijota Martínez, María Carmen
A1 Lakomá, Jarmila
A1 Baars, Sigrid
A1 Garcia Alonso, Luis
A1 Cabedo, Hugo
A2 Faivre Sarrailh, Catherine
AB During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. How such a system works in coordination is not well understood. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans. Here we explore the specificity of the molecular interaction between L1CAM and the erbB receptor family. We show that L1CAM binds physically erbB receptors in both heterologous systems and the mammalian developing brain. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Interestingly, binding of L1CAM to erbB enhances its response to neuregulins. During development this may synergize with the activation of erbB receptors through L1CAM homophilic interactions, conferring diffusible neuregulins specificity for cells or axons that interact with the substrate through L1CAM
PB Public Library of Science
SN 1932-6203
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/92548
UL https://hdl.handle.net/20.500.14352/92548
LA eng
NO Donier, Emanuelle, et al. «L1CAM Binds ErbB Receptors through Ig-Like Domains Coupling Cell Adhesion and Neuregulin Signalling». PLoS ONE, editado por Catherine Faivre-sarrailh, vol. 7, n.o 7, julio de 2012, p. e40674. https://doi.org/10.1371/journal.pone.0040674.
NO Generalitat Valenciana
NO Ministerio de Ciencia e Innovación (España)
NO Consejo Superior de Investigaciones Científicas 
DS Docta Complutense
RD 18 abr 2025