RT Journal Article
T1 Immunometabolism at the nexus of cancer therapeutic efficacy and resistance
A1 Traba, Javier
A1 Sack, Michael
A1 Waldmann, Thomas
A1 Antón Hurtado, Olga María
AB Constitutive activity of the immune surveillance system detects and kills cancerous cells, although many cancers have developed strategies to avoid detection and to resist their destruction. Cancer immunotherapy entails the manipulation of components of the endogenous immune system as targeted approaches to control and destroy cancer cells. Since one of the major limitations for the antitumor activity of immune cells is the immunosuppressive tumor microenvironment (TME), boosting the immune system to overcome the inhibition provided by the TME is a critical component of oncotherapeutics. In this article, we discuss the main effects of the TME on the metabolism and function of immune cells, and review emerging strategies to potentiate immune cell metabolism to promote antitumor effects either as monotherapeutics or in combination with conventional chemotherapy to optimize cancer management.
SN 1664-3224
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/100930
UL https://hdl.handle.net/20.500.14352/100930
LA eng
NO Traba, J., Sack, M. N., Waldmann, T. A., & Anton, O. M. (2021). Immunometabolism at the nexus of cancer therapeutic efficacy and resistance. Frontiers in Immunology, 12, 657293.
NO This work was supported by the Intramural Research Programs of the National Institutes of Health, National Cancer Institute and National Heart, Lung, and Blood Institute. JT is supported by the Ministry of Science and Innovation (MICINN) of Spain (grants RYC2018-026050-I and PID2019-105665RA-I00).
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO National Institutes of Health (United Kingdom)
NO National Cancer Institute (United Kingdom)
NO National Heart, Lung, and Blood Institute (United Kingdom)
DS Docta Complutense
RD 20 ene 2026