%0 Journal Article
%A Aragoneses Cazorla, Guillermo
%A Vallet Regí, María Dulce Nombre
%A Gómez Gómez, María Milagros
%A González Ortiz, Blanca
%A Luque García, José Luis
%T Integrated transcriptomics and metabolomics analysis revealsthe biomolecular mechanisms associated to the antitumoral potential of a novel silver‑based core@shell nanosystem
%D 2023
%@ Print: 0026-3672 Electronic: 1436-5073
%U https://hdl.handle.net/20.500.14352/73382
%X A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for the antitumor action of a nanosystem based on a Ag core coated with mesoporous silica on which transferrin has been anchored as a targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis has been carried out by gene microarrays and RT-qPCR, while high-resolution mass spectrometry has been used for metabolomics. This multiomics strategy has enabled the discovery of the effect of this nanosystem on different key molecular pathways including the glycolysis, the pentose phosphate pathway, the oxidative phosphorylation and the synthesis of fatty acids, among others.
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