RT Journal Article
T1 Integrated transcriptomics and metabolomics analysis revealsthe biomolecular mechanisms associated to the antitumoral potential of a novel silver‑based core@shell nanosystem
A1 Aragoneses Cazorla, Guillermo
A1 Vallet Regí, María Dulce Nombre
A1 Gómez Gómez, María Milagros
A1 González Ortiz, Blanca
A1 Luque García, José Luis
AB A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for the antitumor action of a nanosystem based on a Ag core coated with mesoporous silica on which transferrin has been anchored as a targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis has been carried out by gene microarrays and RT-qPCR, while high-resolution mass spectrometry has been used for metabolomics. This multiomics strategy has enabled the discovery of the effect of this nanosystem on different key molecular pathways including the glycolysis, the pentose phosphate pathway, the oxidative phosphorylation and the synthesis of fatty acids, among others.
PB Springer
SN Print: 0026-3672 Electronic: 1436-5073
YR 2023
FD 2023-03-13
LK https://hdl.handle.net/20.500.14352/73382
UL https://hdl.handle.net/20.500.14352/73382
LA eng
NO Ministerio de Ciencia e Innovación (MINECO) grants PID2020-114529RBI00 and PID2020-117091RB-I00
NO European Research Council ERC-2015-AdG (VERDI) Proposal No. 694160 (MV-R)
NO CIBER (public research consortium created by ISCIII whose actions are co-funded by the European Regional Development Fund.)
NO Ministerio de Ciencia, Innovación y Universidades [Guillermo Aragoneses-Cazorla received a pre-doctoral fellowship (FPU18/01176)]
NO CRUE-CSIC (Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature)
DS Docta Complutense
RD 4 abr 2025