RT Journal Article T1 Lignocellulosic biorefineries based on multifeedstocks and the biological transformation to multiple products: An overview A1 García-Ochoa Soria, Félix A1 Vergara Alarcón, Priscilla A1 Wojtusik, Mateo A1 Gutiérrez, Soledad A1 Santos Mazorra, Victoria Eugenia A1 Ladero Galán, Miguel A1 Villar Gutiérrez, Juan Carlos AB The evolution of lignocellulosic biorefineries increasing the process complexity and integration through the processing of multiple raw biomass-based materials into several products is described. This critical overview deals with available lignocellulosic feedstocks, pretreatment operations, enzymatic saccharification to monosaccharides and their final transformation into bioethanol and other bio-based products. Aspects as process operating conditions, modes of operation, underlying physical and chemical phenomena, and mathematical modelling are addressed.Pretreatment stage is a key step for any further processing, specially when using multifeedstock. The use of ethanol-water mixtures for biomass fractionation is a promising treatment able to compete with the nowadays more employed pretreatment such as steam explotion and diluted acid processes. Enzymatic saccharification of pretreated biomass has been analysed considering its complexity and selectivity. Its mathematical modelling is described in detail, together with the underlying phenomena, highlighting the importance of mass transfer in a biphasic system. An adequate operation unit design, scale-up and control, and process design and integration can be ensured in this way. Finally, biotransformations of monosaccharides to biofuels and platform chemicals is analysed as they are becoming key processes within bioeconomy, in the framework of integrated biorefinery to fuels, chemicals and materials. PB Elsevier YR 2021 FD 2021-11-01 LK https://hdl.handle.net/20.500.14352/130444 UL https://hdl.handle.net/20.500.14352/130444 LA eng NO Garcia-Ochoa, F., Vergara, P., Wojtusik, M., Gutiérrez, S., Santos, V. E., Ladero, M., & Villar, J. C. (2021). Multi-feedstock lignocellulosic biorefineries based on biological processes: An overview. Industrial Crops and Products, 172, 114062. NO HighlightsLignocellulosic biomass (LCB): a key and complex renewable source of fuels and chemicals.Recycling ethanol-water pretreatment: a low-cost and efficient biomass pretreatment.LCB enzymatic saccharification: an interplay of dynamic and kinetic phenomena.The biorefinery as an opportunity to valorise biomass-waste.Biorefinery biological end processes needs for a techno-scientific approach. NO Agencia Estatal de Investigación NO Comunidad Autónoma de Madrid DS Docta Complutense RD 20 ene 2026