RT Journal Article
T1 A flexible analytical framework for reference-based imputation, delta adjustment and tipping-point stress-testing
A1 García-Hernandez, Alberto
A1 Pérez Pérez, Teresa
A1 Pardo Llorente, M. Del Carmen
A1 Rizopoulos, Dimitris
AB This article addresses the challenge of implementing the treatment policy strategy when subjects are not followed up after treatment discontinuation. This problem can be addressed using reference-based imputation, delta adjustment, and tipping-point analysis. Our new framework tackles this problem analytically. We characterize the process that measures the response regardless of drug discontinuation, Z(t), using its association with two observable processes: time to drug dropout (T∗), and the variable representing the response in a hypothetical world without drug discontinuation Y(t). We define the intervention discontinuation effect (IDE) as the unobservable process that quantifies the difference between Y(t) and Z(t) after T∗. We express various well-known imputation rules as forms of the IDE. We model Y using mixed models and T∗ with the Royston-Parmar model. We build estimators for the marginal mean of Z given the estimated parameters for Y and T∗. We demonstrate that this simple estimator building suits all studied rules and provide guidance to extend this methodology. With the proposed framework, we can analytically resolve a broad range of imputation rules and have right-censored treatment discontinuation. This methodology is more efficient and computationally faster than multiple imputation and, unlike Rubin’s variance estimator, presents no standard error over-estimation.
AB En este estudio se desarrolla un método analítico innovador en los ensayos clínicos con variables respuesta cuantitativa, facilitando el manejo de datos incompletos como consecuencia de un evento intercurrente, mejorando la precisión y evitando sesgos.
PB Taylor & Francis
SN 1946-6315
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/113525
UL https://hdl.handle.net/20.500.14352/113525
LA eng
NO García-Hernandez, A., Pérez, T., Pardo, M. del C., & Rizopoulos, D. (2023). A Flexible Analytical Framework for Reference-Based Imputation, Delta Adjustment and Tipping-Point Stress-Testing. Statistics in Biopharmaceutical Research, 15(4), 781–793. https://doi.org/10.1080/19466315.2022.2151506
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 31 dic 2025