RT Journal Article
T1 Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
A1 Perestrelo, Sara
A1 Amaro, Ana
A1 Brouwer, Michael S. M.
A1 Clemente, Lurdes
A1 Ribeiro Duarte, Ana Sofia
A1 Kaesbohrer, Annemarie
A1 Karpíšková, Renata
A1 López Chavarrías, Vicente
A1 Morris, Dearbháile
A1 Prendergast, Deirdre
A1 Pista, Angela
A1 Silveira, Leonor
A1 Skarżyńska, Magdalena
A1 Slowey, Rosemarie
A1 Veldman, Kees T.
A1 Zając, Magdalena
A1 Burgess, Catherine
A1 Álvarez Sánchez, Julio
AB Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
PB MDPI
SN 2079-6382
YR 2023
FD 2023-03-10
LK https://hdl.handle.net/20.500.14352/107541
UL https://hdl.handle.net/20.500.14352/107541
LA eng
NO Perestrelo, S.; Amaro, A.; Brouwer, M.S.M.; Clemente, L.; Ribeiro Duarte, A.S.; Kaesbohrer, A.; Karpíšková, R.; Lopez-Chavarrias, V.; Morris, D.; Prendergast, D.; et al. Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives. Antibiotics 2023, 12, 552. https://doi.org/10.3390/ antibiotics12030552
NO Author Contributions: Conceptualisation, all authors (A.A., M.S.M.B., L.C., A.S.R.D., A.K., R.K., V.L.-C., D.M., D.P., A.P., L.S., M.S., R.S., K.T.V., M.Z., S.P., C.B. and J.A.); data collection and curation, all authors; formal analysis, S.P., C.B. and J.A.; writing—original draft preparation, all authors.; writing—review and editing, S.P., C.B. and J.A.; supervision, C.B. and J.A. All authors have read and agreed to the published version of the manuscript.Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/antibiotics12030552/s1. Supplementary Data S1: DiSCoVeR ESBL-EC complete database; Supplementary Data S2: Source of data included from contributing partners. References [44,81–85] are cited in the Supplementary Materials.
NO Ministerio de Ciencia, Innovación y Universidades
NO German Federal Institute for Risk Assessment
NO National Institute for Agrarian and Veterinary Research
NO Polish Ministry of Education and Science
NO Environmental Protection Agency, Ireland
DS Docta Complutense
RD 22 abr 2025