RT Journal Article
T1 Early meal timing attenuates high polygenic risk of obesity
A1 Jimenez de la Peña Armada, Rocío Teresa
A1 Rodríguez‐Martín, María
A1 Dashti, Hassan S.
A1 Cascales, Ana Isabel
A1 Scheer, Frank A. J. L.
A1 Saxena, Richa
A1 Garaulet, Marta
AB ObjectiveWe examined whether meal timing is associated with long‐term weight‐loss maintenance and whether meal timing interacts with a genome‐wide polygenic score (PRS‐BMI) on body weight‐related outcomes. We then examined the interaction of meal timing with 97 BMI‐related single‐nucleotide polymorphisms on obesity outcome.MethodsParticipants (N = 1195, mean age 41.07 [SD 12.68] years, female 80.8%, baseline mean BMI 31.32 [SD 5.53] kg/m2) were adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean (ONTIME) study. We developed a PRS‐BMI to assess the genetic risk for obesity and estimated the timing of the midpoint of meal intake. We also calculated the success in long‐term weight‐loss maintenance after a dietary obesity treatment (at least 3 years). Linear regression analyses were performed for association and interaction assessments.ResultsEach hour of delay in meal timing was associated with 2.2% higher long‐term body weight (β [SE] = 2.177% [1.067%]; p = 0.042) (i.e., with lower weight‐loss maintenance following dietary obesity treatment). There was a significant interaction between meal timing and PRS‐BMI (p = 0.008); BMI increased by more than 2 kg/m2 for every hour of delay in meal timing in individuals with high PRS‐BMI (β [SE] = 2.208 [0.502] kg/m2; p = 1.0E‐5), whereas no associations were evident for those with lower genetic risk.ConclusionsMeal timing is associated with weight‐loss maintenance and may influence the association between obesity genetics and BMI. Findings underscore the importance of personalized obesity management.image
PB Wiley
SN 1930-7381
SN 1930-739X
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/126168
UL https://hdl.handle.net/20.500.14352/126168
LA eng
NO De La Peña‐Armada R, Rodríguez‐Martín M, Dashti HS, Cascales AI, Scheer FAJL, Saxena R, et al. Early meal timing attenuates high polygenic risk of obesity. Obesity [Internet]. agosto de 2025 [citado 18 de noviembre de 2025];33(8):1555-66. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/oby.24319
NO Seneca Foundation,Grant/Award Number: 20795/PI/18;
NO NationalInstitute of Diabetes and Digestive and KidneyDiseases, Grant/Award Number: NIDDKR01DK105072
DS Docta Complutense
RD 25 mar 2026