RT Journal Article
T1 Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration
A1 Puell Marín, María Cinta
A1 Barrio De Santos, Ana Rosa
A1 Palomo Álvarez, Catalina
A1 Gómez Sanz, Fernando J.
A1 Clement Corral, Amaya
A1 Pérez Carrasco, María Jesús
AB Purpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD.
PB The Association for Research in Vision and Ophthalmology, Inc.
SN 0146-0404
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/45208
UL https://hdl.handle.net/20.500.14352/45208
LA eng
NO Puell Marín, M. C., Barrio De Santos, A. R., Palomo Álvarez, C. et al. «Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration». Investigative Opthalmology & Visual Science, vol. 53, n.o 11, octubre de 2012, p. 7310. DOI.org (Crossref), https://doi.org/10.1167/iovs.11-8649.
NO Abierto en la web del editor
NO Fundación Investigación Médica Mutua Madrileña
NO Banco Santander-Universidad Complutense de Madrid
DS Docta Complutense
RD 6 oct 2024