RT Journal Article
T1 Pinning of tumoral growth by enhancement of the immune response
A1 Bru Espino, Antonio Leonardo
A1 Albertos, Sonia
A1 López García-Asenjo, J. A.
A1 Brú, Isabel
AB Tumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced strong neutrophilia around the tumor. The neutrophils hindered cell surface diffusion so much that they induced new dynamics compatible with the slower quenched-disorder Edwards-Wilkinson universality class. Important clinical effects were also seen, including remarkably high tumor necrosis (around 80%-90% of the tumor), a general increase in survival time [the death ratio in the control group is 15.76 times higher than in the treated group (equivalent to a Cox's model hazard ratio of 0.85; 95% confidence interval 0.76-0.95, p=0.004)], and even the total elimination of some tumors.
PB American Physical Society
SN 0031-9007
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/49843
UL https://hdl.handle.net/20.500.14352/49843
LA spa
NO Bru Espino, A. L., Albertos, S., López García-Asenjo, J. A. & Brú, I. «Pinning of Tumoral Growth by Enhancement of the Immune Response». Physical Review Letters, vol. 92, n.o 23, junio de 2004, p. 238101. DOI.org (Crossref), https://doi.org/10.1103/PhysRevLett.92.238101.
DS Docta Complutense
RD 9 jun 2025