RT Journal Article
T1 An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment
A1 Veres, Tamás
A1 Voniatis, Constantinos
A1 Molnár, Kristóf
A1 Nesztor, Dániel
A1 Fehér, Daniella
A1 Ferencz, Andrea
A1 Gresits, Iván
A1 Thuróczy, György
A1 Márkus, Bence Gábor
A1 Simon, Ferenc
A1 Nemes, Norbert Marcel
A1 García Hernández, María
A1 Reiniger, Lilla
A1 Horváth, Ildikó
A1 Máthé, Domokos
A1 Szigeti, Krisztián
A1 Tombácz, Etelka
A1 Jedlovszky Hajdu, Angela
AB When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 °C (from 37 °C to 42 °C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation.
PB MPDI
SN 2079-4991
YR 2022
FD 2022-04-26
LK https://hdl.handle.net/20.500.14352/72520
UL https://hdl.handle.net/20.500.14352/72520
LA eng
NO Unión Europea. Horizonte 2020
NO Hungarian National Research, Development and Innovation Office
NO National Research, Development and Innovation Office
NO JHA/Ministry for Innovation and Technology
DS Docta Complutense
RD 25 abr 2025