%0 Journal Article
%A Pachón Angona, Irene
%A Bernard, Paul J.
%A Simakov, Alexey
%A Maj, Maciej
%A Jozwiak, Krzysztof
%A Novotna, Anna
%A Lemke, Carina
%A Gütschow, Michael
%A Martin, Helene
%A Oset Gasque, María Jesús
%A Contelles, José Marco
%A Ismaili, Lhassane
%T Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
%D 2024
%@ 1999-4923
%U https://hdl.handle.net/20.500.14352/111903
%X This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds 4a–l, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxidant capacity, cathepsin S inhibition, and interference with Nrf2 transcriptional activation. Of these MTDLs, 4i emerged as a promising compound, demonstrating robust antioxidant activity, the ability to activate Nrf2-ARE pathways, as well as calcium channel blockade and cathepsin S inhibition. Dihydropyridine 4i represents the first example of an MTDL that combines these biological activities.
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