RT Journal Article
T1 Ascertaining the genetic background of the Celtic-Iberian pig strain: A signatures of selection approach
A1 Arias, Katherine D.
A1 Lee, Hanboreum
A1 Bozzi, Riccardo
A1 Álvarez, Isabel
A1 Gutiérrez García, Juan Pablo
A1 Fernández, Iván
A1 Menéndez, Juan
A1 Beja Pereira, Albano
A1 Goyache Goñi, Félix
AB Celtic-Iberian pig breeds were majority in Spain and Portugal until the first half of the 20th century. In the 1990s, they were nearly extinct as a result of the introduction of foreign improved pig breeds. Despite its historical importance, the genetic background of the Celtic-Iberian pig strain is poorly documented. In this study, we have identified genomic regions that might contain signatures of selection peculiar of the Celtic-Iberian genetic lineage. A total of 153 DNA samples of Celtic-Iberian pigs (Spanish Gochu Asturcelta and Portuguese Bísara breeds), Iberian pigs (Spanish Iberian and Portuguese Alentejano breeds), Cinta Senese pig, Korean local pig and Cosmopolitan pig (Hampshire, Landrace and Large White individuals) were analysed. A pairwise-comparison approach was applied: the Gochu Asturcelta and the Bísara samples as test populations and the five other pig populations as reference populations. Three different statistics (XP-EHH, FST and ΔDAF) were computed on each comparison. Strict criteria were used to identify selection sweeps in order to reduce the noise brought on by the Gochu Asturcelta and Bísara breeds' severe population bottlenecks. Within test population, SNPs used to construct potential candidate genomic areas under selection were only considered if they were identified in four of ten two-by-two pairwise comparisons and in at least two of three statistics. Genomic regions under selection constructed within test population were subsequently overlapped to construct candidate regions under selection putatively unique to the Celtic-Iberian pig strain. These genomic regions were finally used for enrichment analyses. A total of 39 candidate regions, mainly located on SSC5 and SSC9 and covering 3130.5 kb, were identified and could be considered representative of the ancient genomic background of the Celtic-Iberian strain. Enrichment analysis allowed to identify a total of seven candidate genes (NOL12, LGALS1, PDXP, SH3BP1, GGA1, WIF1, and LYPD6). Other studies reported that the WIF1 gene is associated with ear size, one of the characteristic traits of the Celtic-Iberian pig strain. The function of the other candidate genes could be related to reproduction, adaptation and immunity traits, indirectly fitting with the rusticity of a non-improved pig strain traditionally exploited under semi-extensive conditions.
PB Wiley
SN 0931-2668
YR 2023
FD 2023-12-06
LK https://hdl.handle.net/20.500.14352/104426
UL https://hdl.handle.net/20.500.14352/104426
LA eng
NO Arias, K. D., Lee, H., Bozzi, R., Álvarez, I., Gutiérrez, J. P., Fernandez, I., Menéndez, J., Beja-Pereira, A., & Goyache, F. (2024). Ascertaining the genetic background of the Celtic-Iberian pig strain: A signatures of selection approach. Journal of Animal Breeding and Genetics, 141, 96–112. https://doi.org/10.1111/jbg.12829
NO 2023 Acuerdos transformativos CRUE
NO European Commission
DS Docta Complutense
RD 24 abr 2025