%0 Journal Article
%A Lozano, Ana I.
%A Alvarez, Lidia
%A Garcia Abenza, Adrian
%A Guerra, Carlos
%A Kossoski, Fabris
%A Rosado Vélez, Jaime
%A Blanco Ramos, Francisco
%A Oller, Juan Carlos
%A Hasan, Mahmudul
%A Centurion, Martin
%A Weber, Thorsten
%A Slaughter, Daniel S.
%A Mootheril, Deepthy M.
%A Dorn, Alexander
%A Kumar, Sarvesh
%A Limao Vieira, Paulo)
%A Colmenares, Rafael
%A Garcia, Gustavo
%T Electron scattering from 1-Methyl-5-Nitroimidazole: cross-sections for modeling electron transport through potential radiosensitizers
%D 2023
%@ 1661-6596
%U https://hdl.handle.net/20.500.14352/113819
%X In this study, we present a complete set of electron scattering cross-sections from 1-Methyl-5-Nitroimidazole (1M5NI) molecules for impact energies ranging from 0.1 to 1000 eV. This information is relevant to evaluate the potential role of 1M5NI as a molecular radiosensitizers. The total electron scattering cross-sections (TCS) that we previously measured with a magnetically confined electron transmission apparatus were considered as the reference values for the present analysis. Elastic scattering cross-sections were calculated by means of two different schemes: The Schwinger multichannel (SMC) method for the lower energies (below 15 eV) and the independent atom model-based screening-corrected additivity rule with interferences (IAM-SCARI) for higher energies (above 15 eV). The latter was also applied to calculate the total ionization cross-sections, which were complemented with experimental values of the induced cationic fragmentation by electron impact. Double differential ionization cross-sections were measured with a reaction microscope multi-particle coincidence spectrometer. Using a momentum imaging spectrometer, direct measurements of the anion fragment yields and kinetic energies by the dissociative electron attachment are also presented. Cross-sections for the other inelastic channels were derived with a self-consistent procedure by sampling their values at a given energy to ensure that the sum of the cross-sections of all the scattering processes available at that energy coincides with the corresponding TCS. This cross-section data set is ready to be used for modelling electron-induced radiation damage at the molecular level to biologically relevant media containing 1M5NI as a potential radiosensitizer. Nonetheless, a proper evaluation of its radiosensitizing effects would require further radiobiological experiments.
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