RT Journal Article
T1 Pollensomes as natural vehicles for pollen allergens
A1 Prado, Noela
A1 De Linares, C.
A1 Sanz, M.L.
A1 Gamboa, P.
A1 Villalba Díaz, María Teresa
A1 Rodríguez García, Rosalía
A1 Batanero Cremades, Eva
AB Olive (Olea europaea) pollen constitutes one of the most important allergen sources in the Mediterranean countries and some areas of the United States, South Africa, and Australia. Recently, we provided evidence that olive pollen releases nanovesicles of respirable size, named generically pollensomes, during in vitro germination. Olive pollensomes contain allergens, such as Ole e 1, Ole e 11, and Ole e 12, suggesting a possible role in allergy. The aim of this study was to assess the contribution of pollensomes to the allergic reaction. We show that pollensomes exhibit allergenic activity in terms of patients' IgE-binding capacity, human basophil activation, and positive skin reaction in sensitized patients. Furthermore, allergen-containing pollensomes have been isolated from three clinically relevant nonphylogenetically related species: birch (Betula verrucosa), pine (Pinus sylvestris), and ryegrass (Lolium perenne). Most interesting, pollensomes were isolated from aerobiological samples collected with an eight-stage cascade impactor collector, indicating that pollensomes secretion is a naturally occurring phenomenon. Our findings indicate that pollensomes may represent widespread vehicles for pollen allergens, with potential implications in the allergic reaction.
PB American Association of Immunologists
SN 0022-1767
YR 2015
FD 2015-07-15
LK https://hdl.handle.net/20.500.14352/24193
UL https://hdl.handle.net/20.500.14352/24193
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (Spain)
DS Docta Complutense
RD 6 abr 2025