RT Journal Article
T1 Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione
A1 Rodríguez, Hortensia
A1 Martin, Osnieski
A1 Suarez, Margarita
A1 Martín, Nazario
A1 Albericio, Fernando
AB Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields.
PB MDPI
SN 1420-3049
YR 2011
FD 2011-11-21
LK https://hdl.handle.net/20.500.14352/43248
UL https://hdl.handle.net/20.500.14352/43248
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Generalitat de Catalunya
DS Docta Complutense
RD 16 dic 2025