RT Journal Article
T1 Premature aging in chronic kidney disease: the outcome ofpersistent inflammation beyond the bounds
A1 Figuer, Andrea
A1 Bodega, Guillermo
A1 Tato, Patricia
A1 Valera, Gemma
A1 Serroukh Mansouri, Nadia
A1 Ceprián, Noemí
A1 De Sequera Ortiz, Patricia
A1 Morales Ruiz, Enrique
A1 Carracedo Añón, Julia María
A1 Ramírez, Rafael
A1 Alique, Matilde
AB Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversible physiological changes associated with loss of functional, psychological, and social capabilities. Numerous factors, such as oxidative stress, inflammation, and cellular senescence, and an irreversible geriatric syndrome known as frailty, contribute to human body deterioration in aging. The speed of aging may differ between individuals depending on the presence or absence of multiple factors (genetic and/or environment) and the subsequent misbalance of homeostasis, together with the increase of frailty, which also plays a key role in developing chronic diseases. In addition, pathological circumstances have been reported to precipitate or accelerate the aging process. This review investigated the mechanisms involved in the developing pathologies, particularly chronic kidney disease, associated with aging.
PB MDPI
SN 1661-7827, ESSN: 1660-4601
YR 2021
FD 2021-07-29
LK https://hdl.handle.net/20.500.14352/4706
UL https://hdl.handle.net/20.500.14352/4706
LA eng
NO Comunidad de Madrid/ FEDER
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER)
NO Sociedad Española de Nefrología
DS Docta Complutense
RD 8 abr 2025