RT Journal Article
T1 Eph/ephrinB signalling is involved in the survival of thymic epithelial cells
A1 García-Ceca Hernández, José Javier
A1 Alfaro Sánchez, David
A1 Montero Herradón, Sara
A1 Zapata González, Agustín Gregorio
AB The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and their ligands, ephrinsB, in the survival of embryonic and newborn (NB) TECs. Our results conclude that EphB2 and EphB3 are involved in the control of TEC survival and that the absence of these molecules causes increased apoptotic TEC proportions that result in decreased numbers of thymic cells and a smaller-sized gland. Furthermore, in vitro studies using either EphB2-Fc or ephrinB1-Fc fusion proteins demonstrate that the blockade of Eph/ephrinB signalling increases TEC apoptosis, whereas its activation rescues TECs from cell death. In these assays, both heterotypic thymocyte–TEC and homotypic TEC–TEC interactions are important for Eph/ephrinB-mediated TEC survival.
PB Wiley
SN 0818-9641
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/91803
UL https://hdl.handle.net/20.500.14352/91803
LA eng
NO García‐Ceca, Javier, et al. «Eph/ephrinB Signalling Is Involved in the Survival of Thymic Epithelial Cells». Immunology & Cell Biology, vol. 91, n.o 2, febrero de 2013, pp. 130-38. https://doi.org/10.1038/icb.2012.59.
NO Ministerio de Educación y Ciencia (España)
NO Ministerio de Salud y Consumo (España)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025