RT Journal Article
T1 Expression of glucose transporter isoform GLUT‐2 and glucokinase genes in human brain
A1 Roncero Rincón, Isabel
A1 Álvarez García, Elvira
A1 Chowen, Julie A.
A1 Sanz Miguel, María Del Carmen
A1 Rábano, Alberto
A1 Vázquez Pérz, Patricia
A1 Blázquez Fernández, Enrique
AB The glucose transporter isoform-2 (GLUT-2) and glucokinase are considered to be components of a glucose sensor system controlling several key processes, and hence may modulate feeding behaviour. We have found GLUT-2 and glucokinase mRNAs in several brain regions, including the ventromedial and arcuate nuclei of the hypothalamus. GLUT-2, glucokinase and glucokinase regulatory protein mRNAs and proteins were present in these areas as determined by biochemical approaches. In addition, glucose-phosphorylating activity with a high apparent Km for glucose that displayed no product inhibition by glucose-6-phosphate was observed. Increased glycaemia after meals may be recognized by specific hypothalamic neurones due to the high Km of GLUT-2 and glucokinase. This enzyme is considered to be the true glucose sensor because it catalyses the rate-limiting step of glucose catabolism its activity being regulated by interaction with glucokinase regulatory protein, that functions as a metabolic sensor
PB Wiley
SN 0022-3042
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/96203
UL https://hdl.handle.net/20.500.14352/96203
LA eng
NO Roncero I, Alvarez E, Chowen JA, et al. Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J Neurochem. 2004;88(5):1203-1210. doi:10.1046/j.1471-4159.2003.02269.x
DS Docta Complutense
RD 12 jul 2025