RT Journal Article
T1 Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model
A1 Cuesta Sancho, Sara
A1 Kireev, Roman
A1 García Martín, M. Cruz
A1 Forman, Katherine
A1 Escames, Germaine
A1 Vara Ameigeiras, Elena María
A1 Fernández-Tresguerres Hernández, Jesús Ángel
AB This study has investigated the effect of aging on parameters of inflammation, oxidative stress and apoptosis in pancreas obtained from two types of male mice models: senescence-accelerated prone (SAMP8) and resistant mice (SAMR1). Animals of 2 (young) and 10 months of age (old) were used (n = 64). The influence of the administration of melatonin in the drinking water for one month at two different dosages (1 and 10mg/(kg day) on old SAMP8 mice on these parameters was also studied. SAMP8 mice showed with age a significant increase in the relative expression of pancreatic genes involved in inflammation, oxidative stress and apoptosis. Furthermore the protein expression of several NFκB subunits was also enhanced. On the contrary aged SAMR1 mice did not show significant increases in these parameters. Melatonin administration to SAMP8 mice was able to reduce these age related alterations at the two used dosages.
PB Elsevier
SN 0047-6374
YR 2011
FD 2011-10-17
LK https://hdl.handle.net/20.500.14352/99736
UL https://hdl.handle.net/20.500.14352/99736
LA eng
NO Cuesta S, Kireev R, García C, Forman K, Escames G, Vara E, Tresguerres JA. Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model. Mech Ageing Dev. 2011 Nov-Dec;132(11-12):573-82. doi: 10.1016/j.mad.2011.10.005. Epub 2011 Oct 17. PMID: 22024129.
NO Instituto de Salud Carlos III
NO Junta de Andalucía
DS Docta Complutense
RD 18 abr 2025