RT Journal Article
T1 Cognitive training modulates brain hypersynchrony in a population at risk for Alzheimer’s disease
A1 Suárez Méndez, Isabel
A1 Bruña Fernández, Ricardo
A1 López Sanz, David
A1 Montejo, Pedro
A1 Montenegro Peña, María Mercedes
A1 Delgado Losada, María Luisa
A1 Marcos Dolado, Alberto
A1 López Sánchez, Ramón
A1 Maestu Unturbe, Fernando
AB Background: Recent studies demonstrated that brain hypersynchrony is an early sign of dysfunction in Alzheimer's disease (AD) that can represent a proxy for clinical progression. Conversely, non-pharmacological interventions, such as cognitive training (COGTR), are associated with cognitive gains that may be underpinned by a neuroprotective effect on brain synchrony.Objective: To study the potential of COGTR to modulate brain synchrony and to eventually revert the hypersynchrony phenomenon that characterizes preclinical AD.Methods: The effect of COGTR was examined in a sample of healthy controls (HC, n = 41, 22 trained) and individuals with subjective cognitive decline (SCD, n = 49, 24 trained). Magnetoencephalographic activity and neuropsychological scores were acquired before and after a ten-week COGTR intervention aimed at improving cognitive function and daily living performance. Functional connectivity (FC) was analyzed using the phase-locking value. A mixed-effects ANOVA model with factors time (pre-intervention/post-intervention), training (trained/non-trained), and diagnosis (HC/SCD) was used to investigate significant changes in FC.Results: We found an average increase in alpha-band FC over time, but the effect was different in each group (trained and non-trained). In the trained group (HC and SCD), we report a reduction in the increase in FC within temporo-parietal and temporo-occipital connections. In the trained SCD group, this reduction was stronger and showed a tentative correlation with improved performance in different cognitive tests.Conclusion: COGTR interventions could mitigate aberrant increases in FC in preclinical AD, promoting brain synchrony normalization in groups at a higher risk of developing dementia.
PB IOS Press
SN 1387-2877
YR 2022
FD 2022-04-05
LK https://hdl.handle.net/20.500.14352/100357
UL https://hdl.handle.net/20.500.14352/100357
LA eng
NO Suárez-Méndez, Isabel et al. ‘Cognitive Training Modulates Brain Hypersynchrony in a Population at Risk for Alzheimer’s Disease’. 1 Jan. 2022 : 1185 – 1199.
NO Comunidad de Madrid
NO Comisión Europea
DS Docta Complutense
RD 15 abr 2025