RT Journal Article
T1 Improving ocular surface comfort in contact lens wearers
T2 Mejora del comfort en la superficie ocular de usuarios de lentes de contacto
A1 Fernández Jiménez, Elena
A1 Diz Arias, Elena
A1 Peral Cerda, María Asunción
AB PurposeContact lens discomfort (CLD) is a major concern that can lead to the decreased or abandoned use of contact lenses. Contact lens users with dry eye disease are more likely to present with CLD. This study was conducted to evaluate the efficacy of a bioprotective preservative free, hypotonic, 0.15% hyaluronic acid (HA)-3% Trehalose artificial tear in managing dry eye symptoms in contact lens wearers.MethodsA prospective, single-arm, observational pilot study to evaluate the effectiveness of treatment with HA-Trehalose artificial tears in contact lens wearers (N = 33) aged 18–45 years with symptoms of ocular discomfort. Participants used a preservative-free, hypotonic HA-Trehalose artificial tear (1 drop/4 times per day) for 84 days. Participants were assessed using Visual Analogue Scale (VAS) for dry eye symptoms (pain, photophobia, dry eye sensation, blurry vision, foreign body sensation, itching, tingling/burning, and sticky eye feeling), Ocular Surface Disease Index (OSDI), Contact Lens Dry Eye questionnaire (CLDEQ-8), Berkley Dry Eye Flow-Chart (DEFC) on Day 0 and Day 84 and tear break-up time (TBUT), ocular surface staining with fluorescein and lissamine green, tear meniscus evaluation, and visual acuity on Day 0, 35, and 84.ResultsAll VAS symptoms (except tingling/burning and sticky eye feeling), OSDI, CLEDQ-8, and DEFC showed statistically significant (p < 0.05) improvement from baseline (Day 0) to Day 84. Similarly, corneal (fluorescein) and conjunctival (lissamine green) quality improved during the study (p < 0.05 at Day 84 versus baseline). Tear break-up time (TBUT), conjunctival (lissamine green) staining, and tear meniscus decreased but the changes were not statistically significant. Visual acuity did not change during the study. There were no ocular or systemic adverse events.ConclusionsThis study showed that the instillation of a preservative-free, hypotonic, HA-Trehalose artificial tear in contact lenses wearers with dry eye syndrome significantly improved symptoms and reduced associated signs such as corneal and conjunctival staining.
PB Elsevier
SN 1367-0484
YR 2021
FD 2021-11-17
LK https://hdl.handle.net/20.500.14352/4699
UL https://hdl.handle.net/20.500.14352/4699
LA eng
NO Fernández-Jimenez, Elena, et al. «Improving Ocular Surface Comfort in Contact Lens Wearers». Contact Lens and Anterior Eye, vol. 45, n.o 3, junio de 2022, p. 101544. DOI.org (Crossref), https://doi.org/10.1016/j.clae.2021.101544.
NO Laboratorios Théa, Clermont Ferrand (Francia)
NO Crue Universidades Españolas-Consejo Superior de Investigaciones Científicas (Acuerdos Transformativos 2021)
DS Docta Complutense
RD 9 abr 2025