RT Journal Article
T1 Empowering Electrochemical Biosensing throughNanostructured or Multifunctional Nucleic Acid or PeptideBiomaterials
A1 Campuzano Ruiz, Susana
A1 Pedrero Muñoz, María
A1 Barderas, Rodrigo
A1 Pingarrón Carrazón, José Manuel
AB Electrochemical biosensors continue to evolve at an astonishing pace, consolidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms of sensitivity, selectivity, simplicity, response time, and antifouling ability, making them suitable for getting a foothold in real-world applications. The design and exploitation of nanostructured or multifunctional nucleic acid or peptide biomaterials is playing a determinant role in these achievements. With the aim of highlighting the potential and opportunities of these biomaterials, this perspective article critically discusses and overviews the electrochemical biosensors reported since 2019 involving nanostructured and multifunctional DNA biomaterials, multifunctional aptamers, modern peptides, and CRISPR/Cas systems. The use of these biomaterials as recognition elements, electrode modifiers (acting as linkers or creating scaffolds with antifouling properties), enzyme substrates, and labeling/carrier agents for signal amplification is discussed through rationally and strategically selected examples, concluding with a personal perspective about the challenges to be faced and future lines of action.
PB Wiley
SN 2365-709X
YR 2022
FD 2022-04-28
LK https://hdl.handle.net/20.500.14352/71436
UL https://hdl.handle.net/20.500.14352/71436
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia e Innovación (MICINN)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III (ISCIII)
DS Docta Complutense
RD 8 may 2024