RT Journal Article
T1 Importance of cardiac imaging assessment of epicardial adipose tissue after a first episode of myocardial infarction
A1 Islas, Fabián
A1 Gutiérrez, Eva
A1 Cachofeiro Ramos, María Victoria
A1 Martínez Martínez, Ernesto
A1 Marín, Gema
A1 Olmos, Carmen
A1 Carrión, Irene
A1 Gil, Sandra
A1 Mahía, Patricia
A1 Cobos, Miguel Ángel
A1 Agustín, Alberto de
A1 Luaces, María
A1 Luaces Méndez, María
AB Background: Over the past years, information about the crosstalk between theepicardial adipose tissue (EAT) and the cardiovascular system has emerged.Notably, in the context of acute myocardial infarction (AMI), EAT might havea potential role in the pathophysiology of ventricular structural changes andfunction, and the clinical evolution of patients. This study aims to assess theimpact of EAT on morpho-functional changes in the left ventricle (LV) and theoutcome of patients after an AMI.Methods: We studied prospectively admitted patients to our hospitalwith a first episode of AMI. All patients underwent percutaneous coronaryintervention (PCI) during admission. Transthoracic echocardiography (TTE)was performed within 24–48 h after PCI, as well as blood samples to assesslevels of galectin-3 (Gal-3). Cardiac magnetic resonance (CMR) was performed5–7 days after PCI. Clinical follow-up was performed at 1 and 5 years after MI.Results: Mean age of our cohort (n = 41) was 57.5 ± 10 years, and 38(93%) were male. Nine patients had normal BMI, 15 had overweight (BMI25–30), and 17 were obese (BMI > 30). Twenty three patients (56%) had ≥4 mm thickness of EAT measured with echo. In these patients, baseline leftventricular ejection fraction (LVEF) after AMI was significantly lower, as well asglobal longitudinal strain. EAT thickness ≥ 4 m patients presented larger infarctsize, higher extracellular volume, and higher T1 times than patients with EAT< 4 mm. As for Gal-3, the median was 16.5 ng/mL [12.7–25.2]. At five-yearfollow-up 5 patients had major cardiac events, and all of them had EAT ≥ 4 mm.Conclusions: Patients with EAT >4 mm have worse LVEF and GLS, larger infarctsize and longer T1 values after a MI, and higher levels of Gal-3. EAT >4 mmwas an independent predictor of MACE at 5-year follow-up. EAT thicknessis a feasible, noninvasive, low-cost parameter that might provide importantinformation regarding the chronic inflammatory process in the myocardiumafter an infarction.
PB Frontiers
YR 2022
FD 2022-11-14
LK https://hdl.handle.net/20.500.14352/134022
UL https://hdl.handle.net/20.500.14352/134022
LA eng
NO Islas F, Gutiérrez E, Cachofeiro V, Martínez-Martínez E, Marín G, Olmos C, et al. Importance of cardiac imaging assessment of epicardial adipose tissue after a first episode of myocardial infarction. Front Cardiovasc Med 2022;9:995367. https://doi.org/10.3389/fcvm.2022.995367
DS Docta Complutense
RD 1 abr 2026