TY - JOUR AU - Sevillano Fernández, David AU - Aguilar, Lorenzo AU - Alou Cervera, Luis AU - Giménez, María José AU - González, Natalia AU - Torrico, Martha AU - Cafini, Fabio AU - Fenoll, Asunción AU - Coronel, Pilar AU - Prieto, José AU - Eleftherios Mylonakis PY - 2008 DO - 10.1371/journal.pone.0002717 SN - 1932-6203 UR - https://hdl.handle.net/20.500.14352/107146 T2 - High protein binding and cidal activity against penicillin-resistant S. pneumoniae: a cefditoren in vitro pharmacodynamic simulation AB - Background: Although protein binding is a reversible phenomenon, it is assumed that antibacterial activity is exclusively exerted by the free (unbound) fraction of antibiotics.Methodology/principal findings: Activity of cefditoren, a highly protein... LA - eng M2 - e2717 PB - PLOS TI - High Protein Binding and Cidal Activity against Penicillin-Resistant S. pneumoniae: A Cefditoren In Vitro Pharmacodynamic Simulation TY - journal article VL - 3 ER -