%0 Journal Article
%A Kappes, Dietmar J
%A Alarcón, Balbino
%A Regueiro González-Barros, José Ramón
%T T lymphocyte receptor deficiencies
%D 1995
%@ 0952-7915
%U https://hdl.handle.net/20.500.14352/107434
%X Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules
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