%0 Journal Article
%A Ruano, Jessica Louzame
%A Bejarano, Leire
%A Serrano, Rosa
%A Diaz, Ruth Alvarez
%A Flores Landeira, Juana María
%A López, Ana Cayuela
%A Blasco, Maria A.
%T Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles
%D 2025
%U https://hdl.handle.net/20.500.14352/125250
%X TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism
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