RT Journal Article
T1 Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles
A1 Ruano, Jessica Louzame
A1 Bejarano, Leire
A1 Serrano, Rosa
A1 Diaz, Ruth Alvarez
A1 Flores Landeira, Juana María
A1 López, Ana Cayuela
A1 Blasco, Maria A.
AB TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism
PB Impact Journals
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/125250
UL https://hdl.handle.net/20.500.14352/125250
LA eng
NO Ruano, J. L., Bejarano, L., Serrano, R., Diaz, R. A., Flores, J. M., López, A. C., & Blasco, M. A. (2025). Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles. Aging, 17(9), 2410–2429. https://doi.org/10.18632/aging.206320
NO Author Contributions: MAB, JL and LB had the original idea. MAB secured funding and supervised the research. JL analyzed the results, wrote the paper and performed the experiments. RS was responsible for animal maintenance and assisted with animal experimentation. JMF performed pathological analysis. ACL developed and analyzed the confocal microscopy images, and RAD performed the bioinformatics analysis.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
NO Fundación Botín (España)
NO Fundación Humanismo y Ciencia
DS Docta Complutense
RD 8 jun 2026