RT Journal Article
T1 Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities
A1 Kumar, Rahul
A1 Cogolludo Torralba, Ángel Luis
A1 Pérez Vizcaíno, Francisco
A1 Morales Cano, Daniel
A1 Dhillon, Navneet K.
A2 Kenneth Stapleford, 
AB The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.
PB Plos
SN 1553-7374
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/93014
UL https://hdl.handle.net/20.500.14352/93014
LA eng
NO Kumar R, Aktay-Cetin Ö, Craddock V, Morales-Cano D, Kosanovic D, et al. (2023) Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLOS Pathogens 19(1): e1011063. https://doi.org/10.1371/journal.ppat.1011063
DS Docta Complutense
RD 6 abr 2025